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O que (quem) é GCM transcription factors - definição
GCM transcription factors
PROTEIN FAMILY
In molecular biology, the GCM transcription factors are a family of proteins which contain a GCM motif. The GCM motif is a domain that has been identified in proteins belonging to a family of transcriptional regulators involved in fundamental developmental processes which comprise Drosophila melanogaster GCM and its mammalian homologues (human GCM1 and GCM2).
General transcription factor
TRANSCRIPTION FACTOR THAT BINDS TO ANY SITE OR TO A SPECIFIC SITE ON DNA TO ACTIVATE, MODERATE, REGULATE, OR MODULATE TRANSCRIPTION
Transcription factors, general; Basal transcription factor; General transcription factors
General transcription factors (GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific sites (promoter) on DNA to activate transcription of genetic information from DNA to messenger RNA. GTFs, RNA polymerase, and the mediator (a multi-protein complex) constitute the basic transcriptional apparatus that first bind to the promoter, then start transcription.
Transcription factor
![''lac'' repressor]] binds its target DNA sequence (gold) in the major groove using a [[helix-turn-helix]] motif. Effector molecule binding (green) occurs in the regulatory domain (labeled). This triggers an allosteric response mediated by the linker region (labeled).](https://commons.wikimedia.org/wiki/Special:FilePath/LacI Dimer Structure Annotated.png?width=200 "''lac'' repressor]] binds its target DNA sequence (gold) in the major groove using a [[helix-turn-helix]] motif. Effector molecule binding (green) occurs in the regulatory domain (labeled). This triggers an allosteric response mediated by the linker region (labeled).")
![DNA-binding domains]] of transcription factors](https://commons.wikimedia.org/wiki/Special:FilePath/Transcription factors DNA binding sites.svg?width=200 "DNA-binding domains]] of transcription factors")
PROTEIN THAT BINDS TO DNA AND REGULATES GENE EXPRESSION BY PROMOTING OR SUPPRESSING TRANSCRIPTION
Transcription factors; Basal factor; Upstream transcription factor; Trans-activator; Upstream binding factor; Upstream stimulatory factors; Promoter factor; TFBS; Gene transcription factor; Sequence-specific DNA-binding factor; Transcription factor protein; Signal-sensing domain; Transactivation factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism.
